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ANGELA MITCHELL, PH.D.

Principle Investigator

Education

Postdoctoral Research Fellow

Princeton University

Ph.D. in Microbiology and Immunology

University of North Carolina at Chapel Hill

B.S. in Biotechnology

Summa cum Laude, Honors in the Discipline

Elizabethtown College

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Publications

# Corresponding author; Mitchell Lab Member; * Equal Contributions

  • Morris KN & Mitchell AM#. (2023) Phosphatidylglycerol is the lipid donor for synthesis of phospholipid-linked enterobacterial common antigen. J Bacteriol. 205(1): e00403-22.

  • Bautista DE*, Carr JF*, Mitchell AM#. (2021) Suppressor Mutants: History and Today’s Applications. EcoSal Plus. 9(2): eESP-0037-2020.

  • Rai AK, Carr JF*, Bautista DE*, Wang W, Mitchell AM#. (2021) ElyC and cyclic enterobacterial common antigen regulate synthesis of phosphoglyceride-linked enterobacterial common antigen. mBio. 12(6): e02846-21

  • Rai AK & Mitchell AM#. (2020) Enterobacterial common antigen: synthesis and function of an enigmatic molecule. mBio. 11(4): e01914-20.

  • Grimm J, Shi H, Wang W, Mitchell AM, Wingreen NS, Huang KC, Silhavy TJ. (2020) The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in Escherichia coli. Proc Natl Acad Sci U S A. 117(43): 26907-26914.

  • Hart EM*, Mitchell AM*, Konovalova A, Grabowicz M, Sheng J, Han X, Rodriguez-Rivera FP, Schwaid AG, Malinverni JC, Balibar CJ, Bodea S, Si Q, Wang H, Homsher MF, Painter RE, Ogawa AK, Sutterlin H, Roemer T, Black TA, Rothman DM, Walker SS, & Silhavy TJ. (2019) A small molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier. Proc Natl Acad Sci U S A. 116(43): 21748-21757.

         Nature News and Views highlight

         F1000Prime recommendation 

  • Mitchell AM & Silhavy TJ. (2019) Envelope stress responses: balancing damage repair and toxicity. Nat Rev Microbiol. 17(7): 417–428.

  • May KL, Lehman KM, Mitchell AM, & Grabowicz M. (2019) A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane. mBio. 10(3): e00618-19.

       Associated commentary

  • Silhavy TJ & Mitchell AM. (2019) Genetic analysis of protein translocation. Protein J. 38(3):217-228.

  • Mitchell AM, Srikumar T, & Silhavy TJ. (2018) Cyclic enterobacterial common antigen maintains the outer membrane permeability barrier of Escherichia coli in a manner controlled by YhdP. mBio. 9(4): e01321-18.

       Associated commentary

  • Mitchell AM, Wang W, & Silhavy TJ. (2017) Novel RpoS-dependent mechanisms strengthen the envelope permeability barrier during stationary phase. Journal of Bacteriology. 199(2): e00708-16.

  • Konovalova A, Mitchell AM, & Silhavy TJ. (2016) A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane. eLife. 5: e15276.

  • Xiao PJ, Mitchell AM, Haung L, Li C, & Samulski RJ. (2016) Disruption of microtubules post virus entry enhances adeno-associated virus vector transduction. Human Gene Therapy. 27(4): 309-24.

  • Mitchell AM, Moser R, Samulski RJ, & Hirsch ML. (2016) Stimulation of AAV gene editing via DSB repair. In Hirsch ML, Cathomen T, & Porteus MH (Eds.), Genome Editing: The Next Step in Gene Therapy (pgs. 125-137). ISBN: 978-1-4939-3507-9.

  • Vance MA, Mitchell AM, & Samulski RJ. (2015) rAAV biology, infectivity and therapeutic use from bench to clinic. In Hashad ID (Ed.), Gene Therapy. ISBN: 978-953-51-4380-2

  • Mitchell AM, Hirsch ML, Li C, & Samulski RJ. (2014) The promyelocytic leukemia protein is a cell-intrinsic defense factor inhibiting parvovirus DNA replication. Journal of Virology. 88(2): 925-36.

  • Mitchell AM & Samulski RJ. (2013) Mechanistic insights into the enhancement of adeno-associated virus transduction by proteasome inhibitors. Journal of Virology. 87(23): 13035-41.

  • Mitchell AM, Li C, & Samulski RJ. (2013) Arsenic trioxide stabilizes accumulations of adeno-associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo. Journal of Virology. 87(8): 4571-83.

  • Mitchell AM*, Nicolson SC*, Warischalk JK*, & Samulski RJ. (2010) AAV’s Anatomy: Roadmap for Optimizing Vectors for Translational Success. Current Gene Therapy. 10(5): 319-340.

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