Our newest publication, “Genetic evidence for functional diversification of gram-negative intermembrane phospholipid transporters”, is now available in PLoS Genetics.
In this paper, we investigated differences in phenotypes of the three putative phospholipid transporters, YhdP, TamB, and YdbH, and clearly link there differentiation to phospholipid metabolism. We find that a cold sensitivity found in the absence of YhdP and a fatty acid metabolism regulator requires the presence of TamB and that increased levels of saturated phospholipids and cardiolipin are involved in the phenotype. We propose a model in which the phospholipid transporters have different substrate transport preferences.
Congradulations to Ashutosh Rai, a former Mitchell Lab Postdoc, and Haley Bennett, Mitchell Lab Graduate Student, on this publication. Also, thanks and congratulations to our collaborators on this project, Misha Bogdanov and Katsuhiro Sawasato from UTHealth Houston and Genevieve Sparagna from the University of Colorado Anschutz Medical Campus.
You can find the publication here: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011335
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